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Neutron capture therapy clinical development in the world

Zhang Zichu,Jin Congjun,Liu Kai,Zhang Guozhen,Yang Lijun

Strategic Study of CAE 2012, Volume 14, Issue 8,   Pages 100-105

Abstract: treatment situation and evaluation in glioblastoma (GBM), malignant melanoma, recurrent head and neck cancerand metastatic liver cancer were discussed in detail.

Keywords： BNCT     GBM     malignant melanoma     recurent head & neck cancer     metastatic liver cancer    

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Liver-directed treatment is associated with improved survival and increased response to immune checkpointblockade in metastatic uveal melanoma: results from a retrospective multicenter trial

Frontiers of Medicine   Pages 878-888 doi: 10.1007/s11684-023-0993-y

Abstract: Metastases of uveal melanoma (UM) spread predominantly to the liver.Due to low response rates to systemic therapies, liver-directed therapies (LDT) are commonly used forA total of 182 patients with metastatic UM treated with immune checkpoint blockade (ICB) were includedPatients were recruited from prospective skin cancer centers and the German national skin cancer registryICB may be associated with a survival benefit and higher treatment response to ICB in patients with metastatic

Keywords： uveal melanoma     liver-directed therapy     immune checkpoint blockade     SIRT     anti-PD-1     anti-CTLA-4    

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Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 231-239 doi: 10.1007/s11684-022-0939-9

Abstract: evaluate the safety and efficacy of neoadjuvant radiohormonal therapy for oligometastatic prostate cancerIn all, neoadjuvant radiohormonal therapy is well tolerated for oligometastatic prostate cancer.

Keywords： neoadjuvant     radiotherapy     oligometastatic     prostate cancer     radical prostatectomy    

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Pyogenic liver abscess as initial presentation in locally advanced right colon cancer invading the liver

Kai Qu, Chang Liu, Aasef M A Mansoor, Bo Wang, Jincai Chen, Liang Yu, Yi Lv

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 434-437 doi: 10.1007/s11684-011-0157-3

Abstract: Locally advanced colorectal cancer complicated with adjacent organic invasion may remain confined toIn the present paper, we report on a patient with advanced right colon cancer, including liver, gallbladder, and duodenal invasion behind the scene of liver abscess.Common clinical manifestations of colorectal cancer were digestive symptoms and changes in defecationHowever, the clinical manifestation of locally advanced colon cancer was extremely complicated.

Keywords： liver abscess     locally advanced colon cancer     multiorganic invasion    

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γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 262-268 doi: 10.1007/s11684-017-0584-x

Abstract: γδ T cells are enriched in the liver and exhibit liver-specific features.fatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regenerationWe believe that determining the properties and functions of γδ T cells in liver diseasesenhances our understanding of the pathogenesis of liver diseases and is useful for the design of novelγδ T cell-based therapeutic regimens for liver diseases.

Keywords： γδT cells     liver infection     non-alcoholic fatty liver disease     autoimmune hepatitis     liver fibrosis and cirrhosis     liver cancer     liver regeneration    

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Chimeric antigen receptor T cell targeting EGFRvIII for metastatic lung cancer therapy

Zhao Zhang, Jun Jiang, Xiaodong Wu, Mengyao Zhang, Dan Luo, Renyu Zhang, Shiyou Li, Youwen He, Huijie Bian, Zhinan Chen

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 57-68 doi: 10.1007/s11684-019-0683-y

Abstract:

Lung cancer is the most common incident cancer and the leading cause of cancer death.tumor-specific mutation expressed in various types of tumors and has been detected in non-small cell lung cancerThus, EGFRvIII is a potential antigen for targeted lung cancer therapy.EGFRvIII-CART showed significantly efficient antitumor activity against lung cancer cells expressingtargeting EGFRvIII is a potential therapeutic strategy in preventing recurrence and metastasis of lung cancer

Keywords： chimeric antigen receptor T cells     epidermal growth factor receptor     lung cancer     immunotherapy     tumor immunolog    

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Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 138-142 doi: 10.1007/s11684-013-0247-5

Abstract: whether SIPA1 545 C>T polymorphism was associated with overall survival in patients with metastaticbreast cancer.In this study, SIPA1 545 C>T polymorphism was detected in 185 metastatic breast cancer patientsbreast cancer.Our findings indicate that metastatic breast cancer patients with SIPA1 545 T/T genotype have

Keywords： SIPA1     polymorphism     metastatic breast cancer     survival    

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Role of Intrahepatic Regional Immunity in Post-Transplant Cancer Recurrence Review

Jiang Liu,Chung Mau Lo,Kwan Man

Engineering 2022, Volume 10, Issue 3,   Pages 57-64 doi: 10.1016/j.eng.2021.11.012

Abstract:

Hepatic malignancy is a major indication for liver transplantation; however, post-transplant cancer, and post-transplant immunosuppression regimens have been elucidated as risk factors for recurrent livercancer.cell invasiveness and metastasis after liver transplantation.recurrence after liver transplantation.

Keywords： Liver transplantation     Liver cancer     Recurrence     Immunology    

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Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells

Yi Liang,Qisheng Feng,Jian Hong,Futuo Feng,Yi Sang,Wenrong Hu,Miao Xu,Roujun Peng,Tiebang Kang,Jinxin Bei,Yixin Zeng

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 57-62 doi: 10.1007/s11684-015-0389-8

Abstract:

The existence of cancer stem cells, stem-like cancer cells (SLCCs), or tumor-initiating cells is consideredOur previous research demonstrates that SLCCs are inducible by increasing genomic instability in cancer

Keywords： rabbit VX2 liver tumor     mitomycin C     AET     stem-like cancer cells     genomic instability    

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Partial liver transplantation

Nianqiao GONG, Xiaoping CHEN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 1-7 doi: 10.1007/s11684-010-0105-7

Abstract:

Partial liver transplantation, including reduced-size liver transplantation, split liver transplantation, and living donor liver transplantation, has been developed with several innovative techniques becauseSplit liver transplantation provides chances to two or even more recipients when only one liver graftBefore surgery, a series of donor evaluations—including anatomical, liver volume, and liver functionAt different recipient conditions, auxiliary liver transplantation and auxiliary partial orthotopic liver

Keywords： partial liver transplantation     reduced-size liver transplantation     split liver transplantation     living donorliver transplantation    

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Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins

Sandy Leung-Kuen Au, Irene Oi-Lin Ng, Chun-Ming Wong

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 231-241 doi: 10.1007/s11684-013-0253-7

Abstract: modifications of histone, which profoundly affect expression of a wide repertoire of genes critical for cancer

Keywords： liver cancer     epigenetics     histone modifications     polycomb group proteins     enhancer of zeste homolog 2 (EZH2    

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Establishment and drug sensitivity evaluation of murine ascites hepatocarcinoma cell line with high lymphatic metastatic

Hongying ZHANG, Jianwu TANG, Wenting ZHU, Chunxiu HU, Guowang XU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 119-129 doi: 10.1007/s11684-009-0022-9

Abstract: effect of medicine against cells, a new murine ascites hepatocarcinoma cell line with high lymphatic metastaticMurine ascites hepatocarcinoma cell strain with low lymphatic metastatic potential (Hca-P) was subcutaneouslyinoculated into the medioventral line of a mouse 615 and the first generation of metastatic tumor cellsThe lymph node metastatic rate was 100%.

Keywords： murine ascites hepatocarcinoma cell line     metastasis     curcumin     drug sensitivity    

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Clinical Correlates and Prognostic Value of Different Metastatic Sites in Gastric and Colorectal Signet Article

Jingjing Wu, Daiqiong Fang, Da Man, Wenrui Wu, Qing Wang, Yating Li, Jianzhong Ye, Lanjuan Li

Engineering 2020, Volume 6, Issue 9,   Pages 1028-1034 doi: 10.1016/j.eng.2020.06.007

Abstract: its contribution to the cancer-specific survival of gastric SRCC and colorectal SRCC.with those without metastatic disease.In gastric SRCC, distant lymph nodes were the most common metastatic sites.In colorectal SRCC, the liver was the most common metastatic site, and patients with distant lymph nodeIn summary, metastasis is a major contributor to cancer mortality in SRCC.

Keywords： SEER Program     Survival analysis     Signet ring cell carcinoma     Metastases     Colorectal cancer     Gastric cancer    

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NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 249-261 doi: 10.1007/s11684-018-0622-3

Abstract: innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the livernatural killer T cells and their roles in hepatitis B virus and hepatitis C virus infection, autoimmune liverdiseases, alcoholic liver disease, nonalcoholic fatty liver disease, and hepatocellular carcinoma.and indicate the dynamic alteration in the role of natural killer T cells during the progression of liver

Keywords： natural killer T cells     hepatitis B virus and hepatitis C virus infection     autoimmune liver diseases     alcoholicliver disease     nonalcoholic fatty liver disease     hepatocellular carcinoma    

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Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 269-279 doi: 10.1007/s11684-018-0621-4

Abstract:

The liver has been characterized as a frontline lymphoid organ with complex immunological featuressuch as liver immunity and liver tolerance.Liver tolerance plays an important role in liver diseases including acute inflammation, chronic infectionThe liver contains a large proportion of natural killer (NK) cells, which exhibit heterogeneity in phenotypicUnder the setting of liver diseases, NK cells are of great importance for stimulating or inhibiting immune

Keywords： natural killer cell     phenotype     immune activation     immune tolerance     liver diseases    

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Title Author Date Type Operation

Neutron capture therapy clinical development in the world

Zhang Zichu,Jin Congjun,Liu Kai,Zhang Guozhen,Yang Lijun

Journal Article

Liver-directed treatment is associated with improved survival and increased response to immune checkpointblockade in metastatic uveal melanoma: results from a retrospective multicenter trial

Journal Article

Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes

Journal Article

Pyogenic liver abscess as initial presentation in locally advanced right colon cancer invading the liver

Kai Qu, Chang Liu, Aasef M A Mansoor, Bo Wang, Jincai Chen, Liang Yu, Yi Lv

Journal Article

γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Journal Article

Chimeric antigen receptor T cell targeting EGFRvIII for metastatic lung cancer therapy

Zhao Zhang, Jun Jiang, Xiaodong Wu, Mengyao Zhang, Dan Luo, Renyu Zhang, Shiyou Li, Youwen He, Huijie Bian, Zhinan Chen

Journal Article

Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Journal Article

Role of Intrahepatic Regional Immunity in Post-Transplant Cancer Recurrence

Jiang Liu,Chung Mau Lo,Kwan Man

Journal Article

Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells

Yi Liang,Qisheng Feng,Jian Hong,Futuo Feng,Yi Sang,Wenrong Hu,Miao Xu,Roujun Peng,Tiebang Kang,Jinxin Bei,Yixin Zeng

Journal Article

Partial liver transplantation

Nianqiao GONG, Xiaoping CHEN

Journal Article

Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins

Sandy Leung-Kuen Au, Irene Oi-Lin Ng, Chun-Ming Wong

Journal Article

Establishment and drug sensitivity evaluation of murine ascites hepatocarcinoma cell line with high lymphatic metastatic

Hongying ZHANG, Jianwu TANG, Wenting ZHU, Chunxiu HU, Guowang XU

Journal Article

Clinical Correlates and Prognostic Value of Different Metastatic Sites in Gastric and Colorectal Signet

Jingjing Wu, Daiqiong Fang, Da Man, Wenrui Wu, Qing Wang, Yating Li, Jianzhong Ye, Lanjuan Li

Journal Article

NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Journal Article

Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Journal Article